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Focus: IMMUNO-STIMULATORY strategies

In order to enhance the efficacy of immunotherapy, the fundamental mechanisms of cancer related immunosuppression has to be understood.
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Main Players

Currently, different types of immunosuppressor cells, regulatory T-cells, immature dendritic cells (iDC), tumour associated macrophages (TAM) and myeloid derived suppressor cells (MDSC), are discussed as the main players in cancer related immunosuppression.
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Various Mechanisms

The immune balance is generally skewed to a Th2 dominance characterized by cytokines such as IL-4, IL-10 and PGE2.

However, over the years several other immunosuppressor mechanisms such as serum blocking factors, circulating immune complexes, enhanced IL-1Ra production and enhanced intratumoral proteolyticactivity were identified to be of key importance in cancer relatedimmunosuppression. suppressor cells (MDSC), are discussed as the main players in cancer related immunosuppression.

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Therapeutic Strategies

Any relevant model of immunosuppression should consequently not only discuss the novel mechanisms but also incorporate previously documentedsuppressor mechanisms. The various mechanisms whereby tumours evade control by the immune system require different therapeutic strategies, either proper stimulation of the immune system or identification and control of cancer related immunosuppressor mechanisms.

P-3028 – Mechanism of Action

 Based on the knowledge of the P3028 mechanisms, CanImGuide had the additional advantage of being able to also develop several novel biomarkers to predict the treatment responses to various immuno-oncology drugs. This is possible, as the intra-tumor presence of P3028 seems to be a common component in cancers of vastly different types.

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