CanImGuide has developed the proprietary drug P28R,
First, this molecule inhibits the activity of an immunosuppressor produced in malignant tumours, and second, it has a direct immunostimulatory activity.
Focus: IMMUNO-STIMULATORY strategies
CanImGuide is developing a therapeutic platform based around an extraordinary biologic concept and an entirely new mechanism of action for immunomodulation.
We have discovered, and thoroughly demonstrated, that a previously unknown immunosuppressive peptide named P3028 is formed in malignant tumors through the breakdown of albumin. This intra-tumoral albumin peptide binds to the fundamental receptor
(an integrin with a key role in immune cell functioning) and is thereby blocking an important component in the natural immune defense that normally contributes to kill cancer cells
Our proprietary drug, P28R
In tumours, the P28R molecule effectively unblocks the blocking effect of the immunosuppressor molecule P3028. CanImGuide has identified the P3028-structure and demonstrated that P3028 is present in all cancers studied so far; breast cancer, renal cell cancer and malignant melanoma.
The CanImGuide story
CanImGuide Therapeutics AB (CanImGuide) was founded in 2006 in order to further develop new treatments for primarily cancer, based on research carried out by a team led by Professor Leif Håkansson at the University of Linköping, Sweden.
Their research clearly indicated the possibility to predict the therapeutic outcome of immunotherapy based on either intra-tumoural or systemic immune status and it was also shown that the systemic immune status could be used to develop prognostic tests of significant value for cancer patients.
In parallell, fundamental cancer related immunoregulatory mechanisms were investigated, which resulted in the detection of several new therapeutic targets in cancer as well as inflammatory diseases.
Based on these observations the potential role of suppressive peptide sequences in cancer immunosuppression was further explored and the potent, suppressive peptide P3028 was discovered. Peptide 3028 has a dual mechanism of action, binding to two receptors of fundamental importance for the function of immune cells with the potential to suppress several steps in initiation and up-regulation of an immune response.
Antibodies to the suppressive peptide 3028 were developed and these antibodies were, in a human ex vivo model, shown to efficiently overcome this type of immunosuppression. A low molecular weight substance directed against this structure comprises a lead drug candidate for treatment of immunosuppression in cancer patients. This therapeutic strategy will enhance immune mediated anti-cancer reactivity and enhance the efficacy of immunostimulatory treatment using interferons, interleukins and vaccination.
In 2013 CanImGuide developed the peptide P28R which targets the P3028-structure and inactivates it.
In vivo studies performed in 2015 demonstrating that P28R executes its anti-cancer effects also following subcutaneous administration (into healthy tissues), achieving systemic treatment effects. This was a fundamental therapeutic breakthrough in the development of P28R.
Toxicological studies conducted without any significant side effects.
Based on the results achieved to date, the company is next planning to initiate its first-in-human clinical trial in patients. This will be a limited size study in patients with head-and-neck cancer. The clinical trial protocol is under review by the Swedish Medical Products Agency and the Ethical Committee and is expected to be ready to be initiated during 2018.
CanImguide will carry out several Non-Clinical development activities which aim to prepare for the clinical development programs and a Phase I/II study. These activities includes a Regulatory Toxicological study, experimental invivo tumour studies, three clinical trials in dog, and a clinical Phase 0 First-In-Human study. All these activities will provide indispensable guidance for the more advanced Phase I/II studies planned to start in 2020.